The Asymmetric Addition of the Sn(II) Enolates of Thioesters to α-Iminoesters. A Convenient Synthesis of Optically Active cis-Substituted β-Lactams.
- 5 February 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 16 (2) , 293-296
- https://doi.org/10.1246/cl.1987.293
Abstract
The asymmetric addition of the Sn(II) enolates derived from thioesters to α-iminoesters having the chiral auxiliary on the nitrogen atom proceeds smoothly to afford syn-β-aminoacid derivatives, which are in turn converted to optically active cis-substituted β-lactams.Keywords
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