Effects of ventricular pacing-induced tachycardia on aortic mechanics in man
Open Access
- 1 August 1998
- journal article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 39 (2) , 506-514
- https://doi.org/10.1016/s0008-6363(98)00115-1
Abstract
Objective: Effects of pacing-induced tachycardia on left ventricular function have been studied extensively. However, little attention has been focused on aortic elastic properties during heart rate increments. The aim was to determine the effects of right ventricular pacing on the aortic elastic properties. Methods: We studied 14 normal subjects (baseline blood pressure, 129/84±10/6 mmHg; aortic diameter, 23.5/21.3±2.4/1.9 mm) at rest, during rapid right ventricular pacing (at five stepwise heart rate increases of 20 bpm every 2 min) and after 5 min recovery. Shifts as well as changes in the slope and the stiffness constant of the pressure diameter (p–d) relation, derived from simultaneous tip-micromanometer aortic pressure recordings and high-fidelity ultrasonic intravascular aortic diameter recordings, were used as indices of aortic stiffness. Wave reflection was also studied. Results: Aortic pulse pressure and strain significantly decreased after pacing-induced tachycardia (pppConclusions: Pacing-induced increases in pulse frequency may result in improved aortic distensibility and aortoventricular coupling.Keywords
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