Effects of hypoxia on passive electrical properties of canine ventricular muscle

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Abstract
The effect of hypoxia, either in the presence or in the absence of glucose, on the passive electrical properties of canine ventricular muscle fibers was examined, employing a single sucrose gap method. The significant changes after 30 min of hypoxia (PO 2=35–45mm Hg) were an increase in the specific internal longitudinal resistance (R i) and a decrease in the space constant (λ). The values during the control (PO 2>450mm Hg) were 198±77 Ω cm forR i and 0.81±0.15 mm for λ, and they changed to 245±90Ω cm and 0.70±0.10mm, respectively, after 30min of hypoxia. Hypoxia decreased the specific membrane resistance (R m), but the changes were not statistically significant. The membrane time constant (τ m ) and capacity (C{imm}) were not affected significantly. The absence of glucose during hypoxia was found to cause more profound changes than hypoxia alone in the passive electrical properties, especiallyR i and λ, suggesting that glucose might counteract the effects of hypoxia on these parameters of ventricular muscles.

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