Do sunlight and vitamin D reduce the likelihood of colon cancer?
Open Access
- 22 November 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in International Journal of Epidemiology
- Vol. 35 (2) , 217-220
- https://doi.org/10.1093/ije/dyi229
Abstract
It is proposed that vitamin D is a protective factor against colon cancer. This hypothesis arose from the inspection of the geographic distribution of colon cancer deaths in the US, which revealed that colon cancer mortality rates were highest in places where populations were exposed to the least amounts of natural light—major cities, and rural areas at high latitudes. The hypothesis is supported by a comparison of colon cancer mortality rates in areas that vary in mean daily solar radiation penetrating the atmosphere. A mechanism involving cholecalciferol (vitamin D3) is suggested. The possibility that an ecological fallacy or another indirect association explains the findings is explored.Keywords
This publication has 8 references indexed in Scilit:
- Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practicesInternational Journal of Cancer, 1975
- Cancer in the United StatesPublished by Harvard University Press ,1972
- EFFECT OF DIETARY FIBRE ON STOOLS AND TRANSIT-TIMES, AND ITS ROLE IN THE CAUSATION OF DISEASEThe Lancet, 1972
- Studies on the mechanism of action of calciferol: V. Turnover time of chick intestinal epithelial cells in relation to the intestinal action of vitamin DExperimental Cell Research, 1972
- Vitamin D3 induced alteration of microvillar membrane lipid compositionBiochemical and Biophysical Research Communications, 1972
- Ecological Correlations and the Behavior of IndividualsAmerican Sociological Review, 1950
- EXPERIMENTAL STUDIES IN ECZEMAArchives of Dermatology and Syphilology, 1929
- Das gegenseitige Kationenverhältnis bei verschiedener Ernährung und bei SäurevergiftungNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1912