Effect of periodate oxidation on hemagglutinating and antibody-producing capacities of certain enteroviruses and reoviruses.

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Abstract
Gentle periodate oxidations of purified preparations of several echovimses; reoviruses; coxsackie virus group B, type 1; and poliovirus type 1 were performed. These altered viruses lost their hemagglutinating capacity, in rabbits were less or noninfective, and produced few or no homotypic-neutralizing or hemag-glutinating-inhibiting antibodies. These experiments further support the concept that there are sugars on the capsids of these viruses which are important for cellular attachment to either erythrocytes or susceptible cells, and that these sugars are the antigenic determinants of these viruses. Definitive confirmation, however, requires biochemical analysis.

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