Bovine Enterovirus-1: characterization, Replication and Cytopathogenic Effects

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Abstract
Summary The biological parameters of a bovine picornavirus, bovine enterovirus-1, are described. The virus is shown to have a rapid growth cycle and to be stable over an extended period at 56 °C and at pH 2 to 10. Within the first hour of infection of cells with BEV-1, cellular protein synthesis was inhibited to less than 40% of normal levels. Maximum release of progeny virus occurred 6 to 8 h post-infection, which coincided with the time of maximum cytopathogenic effects as seen by electron microscopy. The synthesis of virus-specific RNA commenced 1 to 2 h after infection and proceeded exponentially until 5 h after infection. Four virus capsid polypeptides were found together with procapsid proteins, one of which appeared to be a precursor of VP2 and VP4.

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