STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA V: PETHIDINE 100 MG ALONE AND WITH ATROPINE OR HYOSCINE

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Abstract
Pethidine 100 mg has been studied alone and in combination with atropine or hyoscine. Pre-operatively there was a very high incidence of nausea or vomiting after pethidine which was diminished when atropine was given in conjunction and even more when hyoscine was added. Dizziness was also a common toxic effect in all three groups. As judged by lack of excitatory phenomena and hypotension during anaesthesia, pethidine with atropine was the combination of choice. Recovery was delayed in the group given pethidine and hyoscine but these patients had much the lowest incidence of postoperative emetic sequelae.