Human Oögenesis

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Abstract
In humans, the developmental sequence of oögenesis is considerably different from that of spermatogenesis. Oögonia cease to propagate while the female is in the fifth or sixth month of fetal life, and all oöcytes complete the entire process of first meiotic prophase several weeks before the end of gestation. Thus, preparation for segretion of one haploid set from the other is completed during the female’s prenatal life. Oöcytes then enter the long, interphase-like dictyotene stage during which the cytoplasm stores nutrients. At its shortest, the dictyotene stage lasts about 12 years; at its longest, about 50 years. When the estrus cycle begins, one or more oöcytes at a time resume meiosis from diakinesis shortly before being ovulated into the Fallopian tube. Second meiosis is usually completed only after an ovum has been fertilized.

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