INFLUENCE OF HLA-A2 ON EFFECTIVENESS OF PLATELET TRANSFUSIONS IN ALLO-IMMUNIZED THROMBOCYTOPENIC PATIENTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 50  (3) , 407-412
Abstract
Platelet tranfusions from donors selectively mismatched for cross-reactive and certain non-cross-reactive HLA [histocompatibility] antigens were found to be more effective in HLA-A2 negative than in HLA-A2 positive, alloimmunized thrombocytopenid patients. The 2 groups of patients responded equally well to platelets matched for antigens of the HLA-A and B loci. Certain alloimmunized patients negative for HLA-A2 continued to respond satisfactorily to platelets selectively mismatched for non-cross-reactive HLA antigens as long as platelets containing HLA-A2 were avoided. Platelet transfusion support can be provided within a broader range of donor-recipient HLA antigenic disparity to HLA-A2 negative alloimmunized patients than to those who are positive for this antigen.

This publication has 1 reference indexed in Scilit: