Interactions of tumor cells with dendritic cells: balancing immunity and tolerance
Open Access
- 19 October 2007
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 15 (1) , 39-50
- https://doi.org/10.1038/sj.cdd.4402247
Abstract
Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and maintain immunity and tolerance. DCs initiate immune responses in a manner that depends on signals they receive from pathogens, surrounding cells and their products. Most tumors are infiltrated by DCs. Thus, interactions between DCs and dying tumor cells may determine the balance between immunity and tolerance to tumor cells. In addition, DCs also display non-immunologic effects on tumors and the tumor microenvironment. Therefore, improved understanding of the cross talk between tumor cells and DCs may suggest new approaches to improve cancer therapy.Keywords
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