A project for the study of retinal vasculature in old age has been under way for several years. The most recent aspect of this study has been the use of the trypsin digestion technique originally described by Kuwabara and Cogan.1During the course of this investigation several eyes were obtained post mortem that were of special interest. They demonstrate the changes in retinal vasculature resulting from occlusive disease of the central retinal artery and vein, and of their branches. There are four cases, one of each condition, which constitute the material for this paper. Detailed Case Studies 1. Occlusion of the Central Retinal Artery The patient was a white male, aged 85 at the time of death. On Oct 28, 1958, he reported sudden loss of vision in the right eye. Examination of the fundus after dilatation revealed the practically complete occlusion of the central retinal artery. All the