B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) WITH A 14Q+ CHROMOSOME ABNORMALITY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (2) , 235-243
Abstract
An adult patient with acute lymphoblastic leukemia [ALL] associated with a 14q+ marker chromosome is presented. The abnormality resulted from a translocation of material from the long arm of chromosome 11. The leukemic cells were B [bone marrow derived] cells on the basis of surface immunoglobulins, lack of receptors for sheep erythrocytes and a characteristically low level of adenosine deaminase activity. In other patients with ALL in whom chromosome banding was done, a 14q+ chromosome was present in only 1 instance, also a case of B cell ALL. These 2 cases are the only examples of B cell ALL studied with chromosome banding. The frequent occurrence of a 14q+ abnormality and B cell neoplasms. Cytogenetic analysis may be useful in defining subtypes of ALL and in relating specific chromosomal abnormalities to lymphoproliferative disorders.