A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease
- 1 July 1996
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 47 (1) , 256-259
- https://doi.org/10.1212/wnl.47.1.256
Abstract
We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype.Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations. NEUROLOGY 1996;47: 256-259Keywords
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