Synthesis of stereoselectively labelled citric acids transformable into chiral acetic acids
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1324-1325
- https://doi.org/10.1039/c39830001324
Abstract
The ketones (1b) and (1c) have been transformed into the monodeuteriated citric acids, (4b) and (4c) respectively, which are suitable starting materials for the synthesis of chiral acetic acids and other labelled compounds; under base catalysis, the axial 2-H in (1a) exchanges with deuterium more than 1000 times faster than the axial 2-H in 4-t-butylcyclohexanone.Keywords
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