Spironolactone Crystal Forms
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 11 (4) , 855-864
- https://doi.org/10.3109/03639048509057461
Abstract
Spironolactone was obtained in three polymorphic and five solvated crystalline forms which differed in initial dissolution rate in water by about a factor of 12, the most rapidly dissolving form achieving concentrations about twice the equilibrium solubility; on prolonged contact with water transformation to an hydrated phase occurred. It is suggested that the facility with which spironolactone adopts different crystal forms may be utilised to enhance its dissolution-related oral bioavailability.This publication has 13 references indexed in Scilit:
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