Induction in Rats of Paranasal Sinus Carcinomas With Radioactive Cerium Chloride2
- 1 February 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 58 (2) , 423-427
- https://doi.org/10.1093/jnci/58.2.423
Abstract
A colloidal suspension of radioactive cerium stabilized in the form of hydroxide was inoculated into young Sprague- Dawley rats near the maxillary sinus. Well-differentiated epidermoid carcinomas of the paranasal sinus were obtained in 8 of 12 rats and in 8 of 9 animals that lived more than 200 days. Therefore, this isotope was highly effective in inducing tumors at the site of injection. The uniformity of the histologic type of tumors induced under these experimental conditions was remarkable.Keywords
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