Growth Hormone Response Induced by Synthetic Human Growth Hormone‐Releasing Factor (1–44) in Healthy Dogs

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Abstract
The growth hormone (GH) secretory response to varying doses (1, 5 and 25 .mu.g/kg) of intravenous (i.v.) human GH releasing factor (GRF) (1-44) was measured in four, 16-month-old female dogs and compared to the GH response to placebo (vehicle solubilizing GRF) and standard clonidine test (10 .mu.g/kg i.v.). The rise in plasma GH occurred within 5 minutes with a peak response at 15-30 minutes. However inter-subject variability of the GH response was large in terms of magnitude and time course. By analysis of the areas under the response curves it was shown that GRF 1-44 was as effective in stimulating GH release as clonidine and that a dose of 1 .mu.g/kg GRF 1-44 could be a good choice for use as a standard test dose in the dog.