AUDIOGENIC-SEIZURES IN MICE - INFLUENCE OF AGENTS AFFECTING BRAIN-SEROTONIN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (3) , 437-448
Abstract
Brain serotonin levels and susceptibility to audiogenic seizures were examined in a strain of inbred audiosusceptible mice and in control mice at intervals from 2 h to 1 wk after treatment with several agents known to modify serotonin metabolism. Although p-chlorophenylalanine produced a gradual decrease in brain serotonin there appeared to be no temporal correlation between this effect and the rapid reduction in seizure susceptibility. 5-Hydroxytroptophan and tranylcypromine led to significant increases in serotonin, but only the former caused a proportional reduction in seizure activity. Reserpine and .alpha.-propyldopacetamide decreased serotonin levels but only reserpine caused an intensification of seizure activity proportional to serotonin changes. Effects of 5-hydroxytryptophan and reserpine on seizure susceptibility appear to be linked to observed brain serotonin levels.

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