Joint Action of SKF 525-A and Sesamex with Insecticides in Susceptible and Resistant House Flies12

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Abstract
SKF 525-A (2-(diethylamino) ethyl 2,2-diphenylvalerate hydrochloride) and sesamex enhanced the action of the following compounds in both susceptible (S) and polyresistant (R) house flies, Musca domestica (L.): Dilan® (a mixture of 1 part of 1,1-bis (p-chlorophenyl)-2-nitropropane (Prolan®) and 2 parts of 1,1-bis (P-chlorophenyl)-2-nitrobutane (Bulan®)), pyrethrins, carbaryl, Mobil MCA-600 (benzo[b]thien-4-yl methylcarbamate),Pyrolan® (3-methyl-1-pheny1pyrazol-5-yl dimethylcarbamate), Isolan® (l-isopropyl-3-methyl-5-pyrazolyl dimethylcarbamate), HRS 1422 (3,5-diisopropylphenyl methylcarbamate), Zectran® (4-dimethylamino-3,5-xylyl methylcarbamate), diazinon, dimetilan, and lindane. Dieldrin, dioxathion, and endosulfan were synergized in susceptible flies only. Sesamex, but not SKF 525-A, appeared to increase the toxicity of dichlorvos slightly in both S and R flies. Parathion action was antagonized in R flies, but not in S flies, by both SKF 525-A and sesamex. Dimethoate was synergized in S flies by sesamex, and antagonized by SKF 525-A, whereas in R flies both compounds synergized dimethoate. In general, sesamex was a more potent synergist than SKF 525-A. In both R and S flies, sesamex and SKF 525-A antagonized the action of CL 43064 (cyclic ethylene (diethoxyphosphinothioyl) dithioimidocarbonate), CL 47031 (cyclic ethylene (diethoxyphosphinyl) dithioimidocarbonate), and CL 38906 (cyclic S,S-ethylene dithiocarbonate O-(methylcarbamoyl) oxime), with SKF 525-A generally being the more effective antagonist. The possible influence of resistance mechanisms on the responses of the resistant strain is discussed.