Expression of oestrogen receptor-alpha and -beta in ovarian endometriomata

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Abstract
The contribution of oestrogen receptor (ER) isoforms, ER-α and ER-β, in oestrogen-dependent development and growth of ovarian endometriomata, is unknown. Therefore, we examined the expression of ER-α and ER-β in ovarian endometriomata and normal uterine endometrium. ER-α and ER-β were shown to be dominantly expressed in the nuclei of the epithelial lining cells of ovarian endometrioma and of the glandular cells of normal uterine endometrium. ER-β was expressed at a much lower level than ER-α in the glandular cells of normal uterine endometrium, while ER-β was expressed at a slightly lower level than ER-α in the epithelial lining cells of ovarian endometrioma. In normal uterine endometrium, ER-β mRNA was expressed at a much lower level than ER-α mRNA, and the expression pattern of ER-β mRNA during the menstrual cycle was similar to that of ER-α mRNA. On the other hand, ER-β mRNA expression was significantly higher and over a much greater range in ovarian endometriomata (P < 0.05) than in normal uterine endometrium during the menstrual cycle, while ER-α mRNA expression was relatively lower and more random. Therefore, in ovarian endometriomata, oestrogen action via ER-α cascades seems to be partially damaged, as the expression of ER-α mRNA does not respond to endocrinological alterations during the menstrual cycle, while the relative over-expression of ER-β might be related to a unique oestrogen-dependent growth and spreading of ovarian endometriomata.

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