DIABETOGENIC EFFECT OF PURIFIED GROWTH HORMONE1,2

Publisher Website
Google Scholar
Abstract
In intact dogs, highly purified, crystalline growth hormone in a daily dose of 3.5 mg./kg., after an interval of 2-4 days, elicits marked diabetic responses, with hyperglycemia, glycosuria, polyuria and ketonuria. Evidence is presented that for the dog, the growth hormone is the important diabetogenic substance of bovine anterior pituitary glands, both with respect to activity and to the total amt. present in the gland. ACTH elicits signs of diabetes (hyperglycemia and glycosuria) which are much less intense than those produced by the growth hormone. The "diabetes" produced by ACTH in dogs differs in character and in severity from that produced by the growth hormone.