Circulating Insulin-Like Growth Factor I Concentrations in Clinically Severe Obese Patients With and Without NIDDM in Response to Weight Loss
- 1 October 1994
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 26 (10) , 478-480
- https://doi.org/10.1055/s-2007-1001737
Abstract
Earlier studies have demonstrated decreased levels of circulating Insulin-Like Growth Factor-I (IGF-I) in patients with NIDDM and IDDM (Yde 1969; Rieu and Binoux 1985), with a return to normal in those diabetics who achieve improved metabolic control (Rieu and Binoux 1985; Ameil, Sherwin, Hintz, Gertner, Press and Tamborlane 1984) following insulin therapy. One method of improving metabolic control in clinically severe obese NIDDM patients is the gastric bypass procedure (GBP). This study revealed a significant decrease in serum IGF-I concentrations in clinically severe obese patients with NIDDM (obese NIDDM) (105 ng/dl ± 11; n = 29) as compared with clinically severe obese patients with normal glucose tolerances (obese control) (143 ± 11; n = 21) and lean controls (177 ± 14; n = 19) (p1C, insulin, and glucose concurrent with elevations in IGF-I when compared with controls. We conclude that improvement in glucose control led to the increase in IGF-I levels.Keywords
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