Studies on 5-Hydroxytryptamine and 5-Hydroxytryptophan
- 1 December 1958
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 10 (Supplement) , 92T-97T
- https://doi.org/10.1111/j.2042-7158.1958.tb10387.x
Abstract
The 5-HT content and the 5-HTP decarboxylase activity of several tissues of seven mammalian species has been estimated. Whereas 5-HT is concentrated in the spleen and gastrointestinal tract, the highest enzyme activity is found in the kidney, liver, gut and brain. In rats, treatment with reserpine or chlorpromazine lowers the 5-HT content of many tissues and reduces the 5-HTP decarboxylase activity of the kidney, but prolonged treatment with cortisone only lowers the 5-HT content of the skin.Keywords
This publication has 1 reference indexed in Scilit:
- 5‐hydroxytryptamine and tissue mast cellsThe Journal of Physiology, 1957