EFFECT OF CONCANAVALIN-A ON LYMPHOCYTE INTERACTIONS INVOLVED IN ANTIBODY-RESPONSE TO TYPE-3 PNEUMOCOCCAL POLYSACCHARIDE .1. COMPARISON OF SUPPRESSION INDUCED BY CON-A AND LOW-DOSE PARALYSIS

Google Scholar
  • 1 January 1977
    • journal article
    • research article
    • Vol. 118  (3) , 952-956
Abstract
Concanavalin A (Con A) administered at the time of immunization induces suppression of the in vivo [mouse] splenic plaque-forming cell (PFC) response to type III pneumococcal polysaccharide (SSS-III). As with low dose paralysis of the PFC response to SSS-III, Con A-induced suppression could not be demonstrated in congenitally athymic (nu/nu) mice and could be eliminated partially by treatment with anti-lymphocyte serum (ALS). The kinetics for Con A-induced suppression paralleled those for low dose paralysis of the antibody response to SSS-III. Con A-induced suppression is apparently produced in vivo by suppressor T [thymus-derived] cells; this form of suppression apparently shares with low dose paralysis a common pathway through which suppression is mediated.