DIRECT RENAL ACTION OF A PURIFIED PARATHYROID EXTRACT12

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Abstract
In order to determine whether parathyroid hormone evokes phosphattiria in the mammal by a direct effect on the kidney or exerts its action indirectly at an extra-renal site, a highly purified parathyroid extract was administered by slow infusion into one renal artery in the dog. In the majority of animals studied the resultant phosphaturia was exclusively or preferentially unilateral. No systematic changes in renal hemodynamics or plasma phosphate concentration were observed during 3–4 hours of intra-renal infusion. The phosphaturia was accountable for by a diminished rate of phosphate reabsorption, both absolute and relative to the amount of phosphate filtered. It is concluded that PTH acts directly on the kidney in the dog and produces phosphaturia by depressing net phosphate reabsorption by the renal tubule.