Abstract
Thirteen patients with benzodiazepine overdosage received the specific benzodiazepine antagonist Ro 15-1788 [flumazepil]. I.v. administration of 1.5-10 mg reversed the CNS depression induced by different benzodiazepine compounds within 1-2 min of injection. Ro 15-1788 evidently may be an effective tool in the primary management of self-poisoning.

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