On the Epidemiology of Hemophilia and Christmas Disease

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Abstract
A FEW years ago, it became apparent that the symptom complex then called hemophilia could in fact be due to either of two readily separable genetic defects. The commoner disorder, classic hemophilia, is thought by most investigators to be associated with a deficiency in the plasma of antihemophilic factor. The second, rarer, disorder has been called Christmas disease; in this case the patient's plasma lacks Christmas factor, or plasma thromboplastin component. These two disorders seem inseparable clinically, and the pattern of inheritance is the same in both.The relative incidence of classic hemophilia and Christmas disease has been studied by . . .