Protective Effect of Ganglionic Blocking Agents on Traumatic Shock in the Rat.

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Abstract
Summary 1. Significant protection from death due to drum shock in the rat has been demonstrated by intraperitoneal pretreatment with the ganglionic blocking agents, chlori-sondamine, mecamylamine, pentolinium and hexamethonium. 2. TEA failed to provide protection from mortality due to trauma. 3. Significant protective effects were demonstrable only at certain critical dose ranges. 4. The results provide added support to the observations that blockade of the sympathetic nervous system affords protection from the lethal effects of physical trauma.