Response of veins of canine limb to aortic and carotid chemoreceptor stimulation

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Abstract
The reflex response of the limb veins to chemoreceptor stimulation was studied in dogs by following the changes in venous pressure in a hindlimb whose circulation had been arrested temporarily. The aortic chemoreceptor was stimulated by the injection of 1 mg of sodium cyanide at the aortic valve and the subsequent stimulation of the carotid body delayed 15-25 sec. by the insertion of long tubes (1 m) into the carotid arteries. Repeated stimulation and muscle paralysis, after vagotomy with unaided breathing, and after vagotomy with artificial ventilation. The responses from stimulation of both bodies were similar and were unaffected by the changes of ventilation. Initially there was a modest venoconstriction, which with repeated stimulations in 6 of 10 dogs changed to marked venodilatation. The response of ventilation and aortic blood pressure did not alter. The venous responses to aortic and carotid body stimulation were abolished by vagotomy and sinus nerve division, respectively. Provera-tridine injected into the right heart and pulmonary artery elicited no reflex changes in the limb veins but caused systemic hypotension and bradycardia.