BEHAVIOR OF THE CELL SURFACE DURING CLEAVAGE. VII. ON THE DIVISION MECHANISM OF CELLS WITH EXCENTRIC NUCLEI

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Abstract
The eggs of a Japanese sand-dollar, Astricly-peus manni, were used as material for studying the influence of excentricity of the nucleus and subsequently of the mitotic figure on the mechanism of cytokinesis. When these eggs divide the cleavage furrow appears from the side of the cells nearest to the mitotic figure, the asters rotate, causing the animal hemispheres to converge, and the spindle bends, with the convex side directed toward the vegetal pole. It is suggested that the excentricity of the mitotic apparatus causes a difference in the magnitude of the mechanical resistance on the 2 sides of the elongating spindle, which in turn produces the above results. Spindle bending can be induced experimentally in cells which never show it normally by suppressing early cytokinesis so that bi- or multinucleate cells result. In the subsequent cleavage, furrows approach the spindles from their peripheral sides only, and the spindles are bent. Other forms in which spindle bending normally occurs are cited.

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