The effect of noradrenaline, adrenergic blocking agents, and tyramine on the intrarenal distribution of blood flow in the baboon
- 1 May 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 9 (3) , 314-322
- https://doi.org/10.1093/cvr/9.3.314
Abstract
The intrarenal distribution of blood flow in the baboon was measured using the 133xenon clearance technique, and dose-response curves for the various components of renal blood flow were determined during intra-arterial infusions of noradrenaline; the α-adrenergic blocking agent, phenoxybenzamine; the β-adrenergic blocking agent, propranolol; and tyramine which causes the release of endogenous NA. High doses of noradrenaline reduced flow in the outer cortex; this effect was attenuated by phenoxybenzamine, but not by propranolol. Tyramine had no effect. These results suggest that there are α-adrenergic receptors in the resistance vessels of the kidney but are inconsistent with an important role for NA-mediated autonomic control of renal blood flow.Keywords
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