Effect of Undiluted Passage on the Polypeptides of Measles Virus
- 1 July 1979
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 44 (1) , 135-144
- https://doi.org/10.1099/0022-1317-44-1-135
Abstract
Measles virus induces a large polypeptide (L; mol. wt. 180 K), a large glycopolypeptide (H; mol. wt. 80 K), a nucleocapsid associated polypeptide (P; mol. wt. 70 K), a nucleocapsid polypeptide (N; mol. wt. 60 K), a second glycopolypeptide (F0; mol. wt. 60 K), a matrix or membrane polypeptide (M; mol. wt. 37 K) and a small polypeptide (S; mol. wt. 15 K). The second glycopolypeptide (F0) appears to be cleaved in purified measles virus. Defective interfering particles accumulate during passage of measles virus leading to a decrease in the amounts of virus-specific protein synthesized in infected cells. Even in the best preparations of purified measles virus, host proteins are always detected and these become more predominant in preparations with low infectivity.This publication has 8 references indexed in Scilit:
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