CIRCULATING IMMUNE-COMPLEXES IN TOXOPLASMOSIS - DETECTION AND CLINICAL CORRELATES

  • 1 January 1983
    • journal article
    • research article
    • Vol. 52  (1) , 157-163
Abstract
The 125I[complement component]C1q binding test was employed to detect circulating immune complexes in serum of 27 subjects with acute toxoplasmosis. The subjects had no known underlying disease. Elevated C1q binding activity (C1q-BA) was found in the serum of each of 3 adults with the systemic febrile form of toxoplasmosis, 7 of 19 patients with the lymphadenopathic form, and 1 of 4 infants with congenital infection. The patients with the systemic form of illness had significantly greater mean C1q-BA than did those with the lymphadenopathic form (P < 0.001). In 6 episodes of symptomatic toxoplasmosis associated with elevated C1q-BA, follow-up sera were obtained after resolution of all signs and symptoms. Each of these sera showed normalization of C1q-BA. Apparently, immune complex like material is frequently present in the serum of patients with toxoplasmosis and parallels disease activity.