ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS
Top Cited Papers
- 21 July 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 29 (1) , 37-76
- https://doi.org/10.1146/annurev.neuro.29.051605.112834
Abstract
Changes in synaptic efficacy are thought to be crucial to experience-dependent modifications of neural function. The diversity of mechanisms underlying these changes is far greater than previously expected. In the last five years, a new class of use-dependent synaptic plasticity that requires retrograde signaling by endocannabinoids (eCB) and presynaptic CB1 receptor activation has been identified in several brain structures. eCB-mediated plasticity encompasses many forms of transient and long-lasting synaptic depression and is found at both excitatory and inhibitory synapses. In addition, eCBs can modify the inducibility of non-eCB-mediated forms of plasticity. Thus, the eCB system is emerging as a major player in synaptic plasticity. Given the wide distribution of CB1 receptors in the CNS, the list of brain structures and synapses expressing eCB-mediated plasticity is likely to expand.Keywords
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