The Effects of a Single Dose of 2000 Units of Protamine Zinc Insulin Taken by a Diabetic Patient with Suicidal Intent
- 20 October 1949
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 241 (16) , 606-609
- https://doi.org/10.1056/nejm194910202411604
Abstract
THE effects of exceedingly large doses of protamine zinc insulin are known chiefly from patients who have taken excessive amounts by error.1 The literature, however, also lists 2 cases in which huge quantities were taken with suicidal intent, 490 units in the first case and "one bottle" in the other.2 These observations indicate that overdosage with protamine zinc insulin is characterized by a definite sequence of symptoms.Since the effect of protamine zinc insulin on the blood sugar level develops much more slowly than that of unmodified insulin, there is a considerable initial period during which the compensatory mechanisms (chiefly . . .Keywords
This publication has 16 references indexed in Scilit:
- Glucose deficiency as a factor in the production of symptoms referable to the cardiovascular systemAmerican Heart Journal, 1943
- INSULIN AND CEREBRAL DAMAGEArchives of internal medicine (1960), 1940
- Recent Advances in the Biochemistry and Therapeusis of Potassium SaltsNew England Journal of Medicine, 1940
- EFFECT OF PROLONGED INSULIN HYPOGLYCEMIA ON DISTRIBUTION OF WATER AND ELECTROLYTES IN BRAIN AND IN MUSCLEArchives of Neurology & Psychiatry, 1939
- Zur Arbeitstherapie des DiabetesJournal of Molecular Medicine, 1939
- DURATION OF ACTION OF ZINC PROTAMINE INSULINThe Lancet, 1938
- Deleterious Effects of Insulin ShockExperimental Biology and Medicine, 1937
- CLINICAL OBSERVATIONS WITH INSULIN PROTAMINE COMPOUNDJAMA, 1936
- THE DUAL NATURE OF THE ACTION OF INSULIN UPON THE HEARTAnnals of Internal Medicine, 1935
- INSULIN SHOCK AND THE MYOCARDIUMThe Lancet Healthy Longevity, 1931