Cytotoxic T-cell precursors revealed in neonatally tolerant mice.

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Abstract
Induction of neonatal tolerance leads to a profound reduction in cytotoxic T-lymphocyte precursor frequencies against the tolerated alloantigen (tolerogen) as evaluated by limiting-dilution analysis. The curves obtained were linear within the range tested and thus did not yield evidence for any dissociation of cytotoxic precursors from regulatory cell populations. Cytotoxic T-lymphocyte precursor frequencies against the tolerogen increased drastically if the tolerant spleen cells were adsorbed, prior to limiting-dilution culture, on monolayers of syngeneic blasts expressing receptors for the tolerogen; however, this was not true if they were adsorbed on syngeneic blasts against 3rd-party antigens. Apparently, cytotoxic precursor cells against the tolerogen are not clonally deleted in tolerant animals but rather are suppressed by a regulatory cell population that is present at high frequency and presumably acts in an anti-idiotypic fashion.

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