Effect of Hepatitis C Virus Genotype on CD4+T Cell Count in a Cohort of Antiretroviral‐Naive HIV‐1–Infected Individuals

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To the Editor—Over the past few years, there has been substantial controversy regarding whether HIV‐1/hepatitis C virus (HCV)–coinfected individuals experience more‐rapid HIV‐1 disease progression than do HIV‐1–monoinfected individuals [1–3 ]. Yoo et al., in a cohort of largely untreated young HIV‐1/HCV–coinfected participants with hemophilia who were followed for 7 years, observed lower CD4+ T cell counts and a higher risk of AIDS‐related mortality in the participants infected with HCV genotype 1 than in the participants infected with other genotypes [4]. However, as was suggested by the authors, the peculiar characteristics of the participants make the results of the study not directly applicable to other coinfected groups.

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