Mechanism of Production of Candida Lesions in Rabbits

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Abstract
Summary Groups of rabbits were given intratracheal injections of 5 x 107 or 108 yeast-forms of Candida albicans. Morphological transformation from yeasts to mycelia was seen in the tissues within 1 hr of injection. The lungs showed an intense cellular reaction with formation of bronchopneumonia, but this quickly and completely resolved and no progressive lesion developed. Rabbit lung seemed to be highly resistant to C. albicans infection. Fungus entered the blood from the lungs and was disseminated to other viscera. Mycelial forms invaded polymorphonuclear leucocytes, large monocytes, blood vessels and renal tubular epithelium. Proliferation of large monocytes was responsible for fragmentation and destruction of the fungus in all the tissues except the spleen, where there was complete absence of reaction although fungal cultures were positive. The fungus was finally excreted by the kidney in which cortical abscesses developed. These healed slowly by scarring with occasional granuloma formation.

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