Genomic integration of bovine leukemia provirus: comparison of persistent lymphocytosis with lymph node tumor form of enzootic.

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Abstract
Integration of bovine leukemia proviral DNA in the genome of infected [bovine] cells was investigated in cattle affected by either the persistent lymphocytosis or the lymph node tumor form of enzootic bovine leukosis. In persistent lymphocytosis, proviral DNA was integrated at a large number of genomic sites in 1/4-1/3 of circulating leukocytes. In the lymph node tumor form, in contrast, proviral DNA was integrated at 1 or very few sites in the genomes of a larger fraction of both circulating leukocytes and lymph node tumor cells.
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