CEFTRIAXONE EFFECT ON BILIRUBIN-ALBUMIN BINDING
- 1 December 1987
- journal article
- research article
- Vol. 80 (6) , 873-875
Abstract
The effect of ceftriaxone on bilirubin-albumin binding was measured in vitro using the peroxidase method with human serum albumin and a dialysis rate method with adult and newborn serum. Ceftriaxone competes with bilirubin for binding to human serum albumin; the displacement constant is 1.5 .times. 104 L/mol. Therapeutic levels of ceftriaxone decrease the reserve albumin concentration in newborn serum by 39%. These results indicate that ceftriaxone may increase the risk of bilirubin encephalopathy in jaundiced premature infants.This publication has 9 references indexed in Scilit:
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