Rate of Inactivation of Human and Rodent Hepatic Methionine Synthase by Nitrous Oxide
- 1 February 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 68 (2) , 213-216
- https://doi.org/10.1097/00000542-198802000-00006
Abstract
The rate of inactivation of hepatic methionine synthase by nitrous oxide has been determined in 22 patients undergoing laparotomy during general anesthesia, including 70% nitrous oxide. Mean half-time of inactivation was 46 min. Metabolic consequences of nitrous oxide are, thus, critically dependent on the duration of anesthesia, and are unlikely to be significant during exposures of less than 40 min. Inactivation of methionine synthase is very much more rapid in the rat exposed to 505 nitrous oxide, with a half-time of 5.4 min.This publication has 8 references indexed in Scilit:
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