Meiotic and synaptonemal complex studies in a 14/21 translocation carrier

Publisher Website
Google Scholar
Abstract
Meiotic studies in a sterile carrier of a 14/21 translocation showed a meiotic arrest, with degeneration of primary spermatocytes. Silver staining of pachytene cells revealed the presence of a trivalent. Its synaptonemal complex was quite similar to that described in previous light and electron microscopy studies in mammalian species. The observation of a trivalent with pairing in trans‐configuration and the presence of desynaptic synaptonemal complexes in early pachytene could explain the relatively high incidence of non‐disjunction in human D/G translocations and the spermatogenic disintegration sometimes seen in these cases.