Stability constants for metal complexation by isomers of mimosine and related compounds

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Abstract
Stability constants for the Mg2+, Ca2+, Cu2+ and Zn2+ complexes of two isomers (2) and (3) of the defleecing agent mimosine (1) have been sought from potentiometric titrations in aqueous solution, 0.15 M KNO3, at 37°. For the interpretation of the results, complex formation of the simpler ligands 3-hydroxypyridin-4(1H)-one (4), its 2-oxo isomer (5) and DL-α-amino-β-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid (6) was studied. The results with ligand (2) are very similar to those with mimosine, for which a computer blood-plasma model indicates metal chelation under physiological conditions. Ligand (3) is a much weaker complexing agent.

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