OESTROGEN ANTAGONISMS: THE EFFECTS OF OESTRIOL AND 16-EPIOESTRIOL ON OESTRONE-INDUCED UTERINE GROWTH IN SPAYED RATS

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Abstract
SUMMARY: Studies on spayed rats treated simultaneously with mixtures of oestrone and oestriol showed that at low dose levels of oestrone the minor uterine growth response produced is augmented by oestriol; at intermediate doses of oestrone the response is inhibited by oestriol. Large doses of oestrone appear to be unaffected. 16-Epioestriol would appear to show a somewhat similar pattern of activities. We believe that these data suggest that oestriol, and perhaps 16-epioestriol, may act as a sort of biological buffer for the stronger oestrogens, maintaining the uterus when titres of the stronger oestrogens are low, restricting their actions when they are relatively high.