Cardiorespiratory Toxicity Due to Miconazole

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Abstract
Patients (7) with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections [including Candida albicans] developed 8 episodes of major adverse cardiorespiratory and anaphylactic reactions. All the episodes occurred after the 1st dose was administered, and the 7 patients recovered without sequelae after the drug was withdrawn. None had a history of cardiac disease, and with the possible exception of 1 case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found. The rate and length of administration, as well as the dose, should be carefully monitored to avoid these complications.

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