Abstract
Calcium alginate-entrapped mycelium of Penicillium raistrickii i 477 was used for the 15α-hydroxylation of 13-ethyl-gon-4-ene-3,17-dione. The system was tested in 10 batches during 40 days of operation, the catalytic activity could be completely regenerated by incubation in a nutrient medium between several batches.