VASCULAR-PERMEABILITY FACTOR IN LYMPHOCYTE CULTURE SUPERNANTS FROM PATIENTS WITH NEPHROTIC SYNDROME .2. PHARMACOLOGICAL AND PHYSICOCHEMICAL PROPERTIES

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  • 1 January 1975
    • journal article
    • research article
    • Vol. 23  (2) , 73-75
Abstract
Pharmacological properties of the skin reactive factor demonstrated in nephrotic patients are similar to guinea-pig skin reactive factor. This biological activity is not antagonized by anti-histaminic or anti-serotonin drugs. It is inhibited by meclofenamate and pyridinolcarbamate. It is enhanced by diethyldithiocarbamate and normal human serum. It could be an activator of the kinin system. Biochemical studies indicate that it is a pepsin destroyed protein, unaffected by RNase or DNase. Its electrophoretic mobility is that of an albumin or an .alpha.1 globulin.

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