Hepatic resection for small hepatocellular carcinoma: The queen mary hospital experience
- 1 September 1991
- journal article
- Published by Wiley in World Journal of Surgery
- Vol. 15 (5) , 654-659
- https://doi.org/10.1007/bf01789219
Abstract
The clinico-pathological features and long-term results of 39 patients with resected small hepatocellular carcinoma (HCC) managed over 19 years in Hong Kong were retrospectively studied (mean diameter ± standard deviation: 3.6±1.3 cm). Thirty-one patients were symptomatic and the majority (n=33) of them had cirrhosis. When compared with 182 patients with large HCC operated within the same period, these patients with small HCC had a significantly higher incidence of spontaneously ruptured lesions (p3 cm (n=22) or ≤3 cm (n=17) showed no difference in long-term outcome. When compared with large tumors, frequent encapsulation (pp p < 0.03) par rapport aux 182 autres patients atteints de carcinome hépatocellulaire de plus grande taille et opérés pendant la même période. Au plan chirurgical, il a été pratiqué 19 lobectomies majeures et 20 résections plus limitées. Le taux de mortalité, per ou périopératoire, était de 7.7 et 12.8%, respectivement, pour chaque type de résection. La taille des lésions avait peu d'influence sur le pronostic. La survie globale à 1, 3 et 5 ans était de 59%, 28% et 11%, respectivement, tout à fait comparable à ceux des patients ayant un carcinome hépatocellulaire de plus de 5 cm. Lorsque l'on comparait les résultats selon que le diamètre de la tumeur était > 3 cm (n = 22) ou < ou = à 3 cm (n=17), il n'y avait pas de différence staistiquement significative à long terme. Comparés aux tumeurs plus volumineuses, les carcinomes de diamètre < 5 cm étaient plus souvent encapsulés (ppp3 cm (n=22) o≤3 cm (n=17) no se halló diferencia en el resultado a largo plazo. En comparación con los tumores grandes, en los CHC pequeños se encontró encapsulación frecuente (p<0.04) y menos invasión venosa (p<0.03). Puesto que la amplitud de la hepatectomía no produce diferencia en el resultado a largo plazo, la hepatectomía limitada parece ser el procedimiento de escogencia en paciente con CHC pequeños. La provisión de un margen de 1 cm aparece adecuada para asegurar la resección con márgenes histológicamente libres.Keywords
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