Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
- 20 February 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 303 (5661) , 1179-1181
- https://doi.org/10.1126/science.1092089
Abstract
PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine 383 . The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.Keywords
This publication has 23 references indexed in Scilit:
- Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates ChemotaxisCell, 2002
- Tumor Suppressor PTEN Mediates Sensing of Chemoattractant GradientsCell, 2002
- Electrostatic Control of the Membrane Targeting of C2 DomainsMolecular Cell, 2002
- Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζCell, 2001
- PTEN and Myotubularin: Novel Phosphoinositide PhosphatasesAnnual Review of Biochemistry, 2001
- Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinaseBiochemical Journal, 2000
- Crystal Structure of the PTEN Tumor SuppressorCell, 1999
- Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTENScience, 1998
- Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainProceedings of the National Academy of Sciences, 1997
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997