On "genomenclature": a comprehensive (and respectful) taxonomy for pseudogenes and other "junk DNA".
- 15 November 1992
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 89 (22) , 10706-10710
- https://doi.org/10.1073/pnas.89.22.10706
Abstract
Genomic nomenclature has not kept pace with the levels and depth of analyzing and understanding genomic structure, function, and evolution. We wish to propose a general terminology that might aid the integrated study of evolution and molecular biology. Here we designate as a "nuon" any stretch of nucleic acid sequence that may be identifiable by any criterion. We show how such a general term will facilitate contemplation of the structural and functional contributions of such elements to the genome in its past, current, or future state. We focus in this paper on pseudogenes and dispersed repetitive elements, since their current names reflect the prevalent view that they constitute dispensable genomic noise (trash), rather than a vast repertoire of sequences with the capacity to shape an organism during evolution. This potential to contribute sequences for future use is reflected in the suggested terms "potonuons" or "potogenes." If such a potonuon has been coopted into a variant or novel function, an evolutionary process termed "exaptation," we employ the term "xaptonuon." If a potonuon remains without function (nonaptive nuon), it is a "nonaptation" and we term it "naptonuon." A number of examples for potonuons and xaptonuons are given.Keywords
This publication has 34 references indexed in Scilit:
- Sequence Alignment of the G-Protein Coupled Receptor SuperfamilyDNA and Cell Biology, 1992
- Reverse Transcriptase Encoded by a Human Transposable ElementScience, 1991
- Isolation of an Active Human Transposable ElementScience, 1991
- RNA-mediated transfer of the gene coxII from the mitochondrion to the nucleus during flowering plant evolutionCell, 1991
- Bovine corneal protein 54K (BCP54) is a homologue of the tumor-associated (class 3) rat aldehyde dehydrogenase (RATALD)Gene, 1991
- Gene conversion and splice-site slippage in the argininosuccinate lyases/δ-crystallins of the duck lens: members of an enzyme superfamilyGene, 1990
- Retroviral long terminal repeat is the promoter of the gene encoding the tumor-associated calcium-binding protein oncomodulin in the ratJournal of Molecular Biology, 1989
- The enzyme lactate dehydrogenase as a structural protein in avian and crocodilian lensesNature, 1987
- Multiplicity of glutathione S-transferase genes in the rat and association with a type 2 Alu repetitive elementBiochemistry, 1986
- Structural relationship of human interferon alpha genes and pseudogenesJournal of Molecular Biology, 1985